Lyle McCarthy, Seth Rogen

Leonard Nimoy

Cameron Winklevoss, Tyler Winklevoss

Helen Lovejoy, Maude Flanders, Miss Hoover, Luann Van Houten, Nurse, Others, Additional Voices, Elizabeth Hoover, Librarian, Various...

Russell Brand

Candace, Hannah Horvath

Himself

Bret 'The Hitman' Hart

Himself

Professor John Frink, Sr.

Dr. Robert Terwilliger, Sr.

Dr. Zander, Judd Apatow, Paul Rudd

Himself

Himself, Penn Jilette

Himself

Bart Simpson, Nelson Muntz, Ralph Wiggum, Kearney, Todd Flanders, Maggie Simpson, Database, Additional Voices, Kearney Zzyzwicz, Lewis...

Morty Smith, Rick Sanchez

Hugh Hefner

Cecil Terwilliger, Felix

Justin Bieber

Moe Szyslak, Chief Wiggum, Carl, Lou, Comic Book Guy, Apu, Apu Nahasapeemapetilon, Cletus, Carl Carlson, Kirk Van Houten...

Barney Gumble, Chief Wiggum

Santa's Little Helper, Snowball II, African Animals, Baboons, Badger, Barnyard Animals, Buffalo, Cougar, Dolphins, Executive Vice-President...

Martin Prince, Sherri, Terri, Uter, Wendell, Additional Voices, Lewis, Martin, Others, Various...

Himself, Teller

Manjula Nahasapeemapetilon

Nigel Baker-Butcher, Prince Charles, Queen Elizabeth II

Akira, George Takei, Sushi Chef, Waiter, Wink, the Game Show Host

Ellen DeGeneres

Randy Jackson

Judd Apatow