Hugh Hefner

Leonard Nimoy

Lady Gaga

Helen Lovejoy, Maude Flanders, Miss Hoover, Luann Van Houten, Nurse, Others, Additional Voices, Elizabeth Hoover, Librarian, Various...

Russell Brand

Candace, Hannah Horvath

Himself

Dana Scully

Dan Gillick

Professor John Frink, Sr.

Dr. Robert Terwilliger, Sr.

Lyle McCarthy, Seth Rogen

Himself

Himself, Penn Jilette

Himself

Bart Simpson, Nelson Muntz, Ralph Wiggum, Kearney, Todd Flanders, Maggie Simpson, Database, Additional Voices, Kearney Zzyzwicz, Lewis...

Judd Apatow

Himself

Cecil Terwilliger, Felix

Cameron Winklevoss, Tyler Winklevoss

Moe Szyslak, Chief Wiggum, Carl, Lou, Comic Book Guy, Apu, Apu Nahasapeemapetilon, Cletus, Carl Carlson, Kirk Van Houten...

Barney Gumble, Chief Wiggum

Santa's Little Helper, Snowball II, African Animals, Baboons, Badger, Barnyard Animals, Buffalo, Cougar, Dolphins, Executive Vice-President...

Martin Prince, Sherri, Terri, Uter, Wendell, Additional Voices, Lewis, Martin, Others, Various...

Rupert Murdoch

Manjula Nahasapeemapetilon

FBI Investigator

Akira, George Takei, Sushi Chef, Waiter, Wink, the Game Show Host

Ellen DeGeneres

Randy Jackson

Anderson Cooper